Anaemia is the condition of having less than normal number of red blood
cells or less than normal quantity of haemoglobin (Hb) in the blood.
The oxygen-carrying capacity of the blood is therefore decreased.
Most, if not all of us, have had their Hb checked, at least once in our
life. It stupefies me when people (some health workers included) relate
all cases of low Hb to iron deficiency without first ascertaining the
cause.
I recently carried out a Hb estimation for a nurse friend who rebuffed
me and actually doubted my systems after the result showed no
improvement from what it had been half a year earlier despite her
increased intake of iron-rich foods. I really couldn't make out why she
deemed herself immune from other types of anaemia. I thought she would
consider taking further investigations after finding the level to be low
a second time.Call it denial if you wish.
By the way, you may ingest good amounts of iron but have problems with its absorption.
Away from my friend now.
How many people with no medical training know that there exists anaemias
other than iron-deficiency anaemia? This is the lot this article
targets.
In a very simple language I give you a glimpse of some of the other anaemias they seldom mention in those consultation rooms.
Pernicious anaemia;
This is a chronic illness caused by impaired absorption of vitamin B12.
It is a type of megaloblastic anaemia(red blood cells are abnormally
large). Vitamin B12 is necessary in DNA synthesis during red cell
formation. Lack of it leads to impaired DNA synthesis hence the
megaloblastic changes. The causes of this malabsorption of vitamin B12
may be:
1. Absence or lack of intrinsic factor (IF), a protein necessary in vitamin B12 absorption.
2. An autoimmune mechanism- an autoantibody interfers with the normal
uptake of vitamin B12. This vitamin is not absorbed directly but MUST
first associate with a protein called intrinsic factor that is
synthesized by the parietal cells in gastric mucosa. This
vitamin-protein complex is then transported across the intestinal mucosa
where absorption takes place. Plasma cells in the gastric mucosa of
patients with pernicious anaemia secrete an autoantibody specific for
intrinsic factor. This autoantibody combines with intrinsic factor thus
inhibiting its role as a carrier for vitamin B12.
3. Infection with fish tapeworm;-there's competitive absorption of the host's vitaminB12.
Folate(folic acid) deficiency anemia;
It's a type of megaloblastic anemia. Folic acid is necessary for red
blood cell formation(DNA synthesis by the highly dividing cells).
Causes; certain medications, chronic alcoholism, crohn's disease, celiac disease.
Risk factors include;
1. Pregnancy- due to increased demand for folate
2. Eating over-cooked food.
3. Alcoholism- alcohol interferes with the absorption of folate.
4. Poor diet;- poverty-stricken, the elderly and people who do not eat fresh fruits and vegetables.
Autoimmune haemolytic anemias
These occur due to production of antibodies against a person's own red
blood cells. These lead to destruction of one's red blood cells
resulting in a crisis (shortage)
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